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Middle aged and elderly men with low testosterone levels and with pre-diabetes (in which blood glucose levels are above normal but not as high as diagnostic levels for diabetes) are at high risk of developing Type 2 diabetes. Lifestyle measures can retard the development of Type 2 diabetes, but it is not clear if testosterone replacement in such men is even more effective. The T4DM study led by Prof. Gary Wittert, randomised 1000 middle age or older men with low testosterone and pre-diabetes or early Type 2 diabetes to lifestyle alone, including Weight Watchers plans with either testosterone replacement of placebo. The study outcomes (rates of Type 2 diabetes) will be reported soon in 2020.
A high-volume, low-cost approach to participant screening and enrolment: Experiences from the T4DM diabetes prevention trial.
2019 Society for Clinical Trials
Telephone call reminders did not increase screening uptake more than SMS reminders: a recruitment study within a trial.
2019 Journal of Clinical Epidemiology
Testosterone therapy to prevent type 2 diabetes mellitus in at‐risk men (T4DM): Design and implementation of a double‐blind randomized controlled trial.
2018 Diabetes, Obesity and Metabolism